Linked Life Data

14991732

Source:http://linkedlifedata.com/resource/pubmed/id/14991732

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-3-1
pubmed:abstractText
It is accepted that angiogenesis plays an important role in the development of the corpus luteum (CL) and is probably necessary for normal lutein cell function. A number of drugs currently being tested in clinical trials as possible angiogenesis inhibitors were not originally developed with the intention of suppressing tumor angiogenesis. Interferon alpha (IFN-alpha) is one of the notable examples of such 'accidental angiogenesis inhibitors' and daily administration of IFN-alpha is known to suppress tumor growth, tumor vascularization, and down-regulation of various growth factors. We investigated the effects of IFN-alpha treatment on the expression of vascular endothelial growth factor (VEGF), and its receptors KDR and Flt-1, and CD34 in CL during the first week of pseudopregnancy and pregnancy in hormonally induced rat ovaries by immunohistochemistry and Western blot techniques. Basal body temperatures of the drug-treated rats, as an indicator of treatment effect, were determined daily and were increased significantly when compared to controls (38.03 +/- 0.18 vs. 36.6 +/- 0.1 degrees C), respectively. The effect of IFN-alpha treatment was minimal when the entire week was evaluated, however, the expression of VEGF decreased at 3rd, 5th, and 7th days of both pregnancy and pseudopregnancy, when compared to the 1st day, whereas there was not a such alteration in the untreated rats regarding these days. The daily subcutaneous administrations of 672.500 U IFN-alpha2b had minimal effects on the expressions of VEGF, and its two receptors KDR and Flt-1 in either pregnant or pseudopregnant corpora lutea utilizing HSCORE.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1040-452X
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
414-23
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:14991732-Angiogenesis Inhibitors, pubmed-meshheading:14991732-Animals, pubmed-meshheading:14991732-Blotting, Western, pubmed-meshheading:14991732-Corpus Luteum, pubmed-meshheading:14991732-Female, pubmed-meshheading:14991732-Gene Expression Regulation, pubmed-meshheading:14991732-Gonadotropins, pubmed-meshheading:14991732-Horses, pubmed-meshheading:14991732-Humans, pubmed-meshheading:14991732-Immunohistochemistry, pubmed-meshheading:14991732-Injections, Subcutaneous, pubmed-meshheading:14991732-Interferon-alpha, pubmed-meshheading:14991732-Pregnancy, pubmed-meshheading:14991732-Pregnancy, Animal, pubmed-meshheading:14991732-Pseudopregnancy, pubmed-meshheading:14991732-Rats, pubmed-meshheading:14991732-Rats, Wistar, pubmed-meshheading:14991732-Receptors, Vascular Endothelial Growth Factor, pubmed-meshheading:14991732-Recombinant Proteins, pubmed-meshheading:14991732-Vascular Endothelial Growth Factor A
pubmed:year
2004
pubmed:articleTitle
Expressions of VEGF and its receptors in rat corpus luteum during interferon alpha administration in early and pseudopregnancy.
pubmed:affiliation
Department of Histology and Embryology, School of Medicine, Akdeniz University, Antalya, Turkey.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't