Linked Life Data

14991385

Source:http://linkedlifedata.com/resource/pubmed/id/14991385

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-5-12
pubmed:abstractText
Mutations in the PARK7 gene DJ-1 are associated with recessive hereditary Parkinson's disease (PD). Fibrillar inclusions of alpha-synuclein comprise the neuropathological hallmarks of PD and related Lewy body diseases as well as multiple system atrophy (MSA). Moreover, neuronal and glial inclusions containing tau have been observed in alpha-synucleinopathy patients. Using a collection of antibodies against DJ-1, we have performed a comprehensive investigation of DJ-1 in alpha-synucleinopathies and tauopathies. DJ-1 was abundantly expressed in reactive astrocytes of patients with neurodegenerative diseases. Likewise, DJ-1 antiserum immunostained reactive astrocytes that became abundant with disease progression in the brain stem of transgenic mice expressing mutant [A30P]alpha-synuclein. Human Lewy bodies as well as Lewy body-like inclusions in the alpha-synuclein transgenic mice were DJ-1 negative. Neuronal tau inclusions were DJ-1 immunopositive in Pick's disease (PiD), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and Alzheimer's disease. In addition, we found DJ-1-immunopositive glial inclusions in CBD, PSP and MSA. Biochemical extraction experiments revealed the specific presence of insoluble, modified DJ-1 in PiD and MSA. Our results suggest that DJ-1 is up-regulated in reactive astrocytes as well as in neuronal and glial cells with specific alpha-synucleinopathy and tauopathy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0001-6322
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
489-96
pubmed:dateRevised
2007-11-9
pubmed:meshHeading
pubmed-meshheading:14991385-Adult, pubmed-meshheading:14991385-Aged, pubmed-meshheading:14991385-Aged, 80 and over, pubmed-meshheading:14991385-Animals, pubmed-meshheading:14991385-Blotting, Western, pubmed-meshheading:14991385-Epitope Mapping, pubmed-meshheading:14991385-Female, pubmed-meshheading:14991385-Humans, pubmed-meshheading:14991385-Immunohistochemistry, pubmed-meshheading:14991385-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:14991385-Male, pubmed-meshheading:14991385-Mice, pubmed-meshheading:14991385-Mice, Transgenic, pubmed-meshheading:14991385-Middle Aged, pubmed-meshheading:14991385-Multiple System Atrophy, pubmed-meshheading:14991385-Nerve Tissue Proteins, pubmed-meshheading:14991385-Oncogene Proteins, pubmed-meshheading:14991385-Pick Disease of the Brain, pubmed-meshheading:14991385-Synucleins, pubmed-meshheading:14991385-Tauopathies, pubmed-meshheading:14991385-alpha-Synuclein, pubmed-meshheading:14991385-tau Proteins
pubmed:year
2004
pubmed:articleTitle
Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease.
pubmed:affiliation
Institute of Neuropathology, Ludwig Maximilians University of Munich, Munich, Germany.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't