Source:http://linkedlifedata.com/resource/pubmed/id/14989712
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2004-3-1
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| pubmed:abstractText |
Defective function of antigen-presenting cells has been postulated to be one of the non-HLA-linked susceptibility factors for type 1 diabetes mellitus, though the underlying genetic factors remain unclear. SLC11A1 (formerly NRAMP1), a divalent cation transporter, plays a crucial role in macrophage activation. We performed a case-control study in 224 healthy and 95 type 1 diabetic Japanese subjects, examining the length polymorphisms in the promoter region (-377 to -222) of SLC11A1, which may influence transcriptional activity. Alleles designated 2, 3, and 7 have been identified in Japanese subjects. The frequency of allele 7 was significantly higher in subjects with type 1 diabetes (9.47%) than in the healthy controls (4.46%). The difference is more marked in the subpopulation of Japanese subjects with type 1 diabetes; diabetic subjects with at least one protective HLA class II allele and those without any susceptibility HLA class II haplotypes, DR4-DQ4 or DR9-DQ9, had a much higher allele 7 frequency than controls. These findings suggest that the novel promoter polymorphism of SLC11A1 influences the susceptibility to type 1 diabetes in Japanese subjects.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0001-2815
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
63
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
231-6
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:14989712-Adolescent,
pubmed-meshheading:14989712-Adult,
pubmed-meshheading:14989712-Alleles,
pubmed-meshheading:14989712-Case-Control Studies,
pubmed-meshheading:14989712-Cation Transport Proteins,
pubmed-meshheading:14989712-Child,
pubmed-meshheading:14989712-Child, Preschool,
pubmed-meshheading:14989712-Diabetes Mellitus, Type 1,
pubmed-meshheading:14989712-Female,
pubmed-meshheading:14989712-Genetic Predisposition to Disease,
pubmed-meshheading:14989712-Genotype,
pubmed-meshheading:14989712-HLA-DQ Antigens,
pubmed-meshheading:14989712-HLA-DR Antigens,
pubmed-meshheading:14989712-Haplotypes,
pubmed-meshheading:14989712-Humans,
pubmed-meshheading:14989712-Infant,
pubmed-meshheading:14989712-Japan,
pubmed-meshheading:14989712-Male,
pubmed-meshheading:14989712-Polymorphism, Genetic,
pubmed-meshheading:14989712-Promoter Regions, Genetic
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Promoter polymorphism of SLC11A1 (formerly NRAMP1) confers susceptibility to autoimmune type 1 diabetes mellitus in Japanese.
|
| pubmed:affiliation |
Division of Molecular Metabolism and Diabetes, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. ktakahashi@int3.med.tohoku.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|