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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-3-17
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pubmed:abstractText |
The tumor necrosis factor (TNF) family member APRIL binds to the receptors BCMA on B cells and TACI on B and T cells. To investigate the role of APRIL in immunity, we generated APRIL-deficient mice. APRIL(-/-) mice have normal T and B lymphocyte development, normal T and B cell proliferation in vitro, but increased numbers of CD44(hi)CD62L(lo) CD4(+) effector/memory T cells and increased IgG responses to T-dependent antigens. Serum IgA levels were significantly decreased, and serum IgA antibody responses to mucosal immunization with TD antigens and to type 1 T-independent antigens were impaired in APRIL(-/-) mice. APRIL by itself induced IgA as well as IgG1 isotype switching in CD40-deficient IgM(+)IgD(+) sorted B cells. These results suggest that APRIL down-regulates T cell-dependent antibody responses and promotes IgA class switching.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14988498-10359578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14988498-10398604,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3903-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:14988498-Animals,
pubmed-meshheading:14988498-Antigens,
pubmed-meshheading:14988498-Cell Division,
pubmed-meshheading:14988498-Humans,
pubmed-meshheading:14988498-Immunoglobulin A,
pubmed-meshheading:14988498-Immunoglobulin Class Switching,
pubmed-meshheading:14988498-Lymphocytes,
pubmed-meshheading:14988498-Lymphoid Tissue,
pubmed-meshheading:14988498-Mice,
pubmed-meshheading:14988498-Mice, Transgenic,
pubmed-meshheading:14988498-Mutation,
pubmed-meshheading:14988498-Neuropeptides,
pubmed-meshheading:14988498-Nuclear Proteins,
pubmed-meshheading:14988498-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2004
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pubmed:articleTitle |
Impaired IgA class switching in APRIL-deficient mice.
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pubmed:affiliation |
Division of Immunology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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