Source:http://linkedlifedata.com/resource/pubmed/id/14986847
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rdf:type | |
lifeskim:mentions |
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umls-concept:C2697811
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pubmed:issue |
6
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pubmed:dateCreated |
2004-2-27
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pubmed:abstractText |
In rodents, theta rhythm has been linked to the hippocampal formation, as well as other regions, including the anterior cingulate cortex (ACC). To test the role of the ACC in theta rhythm, concurrent measurements of brain electrical activity (EEG) and glucose metabolism (PET) were performed in 29 subjects at baseline. EEG data were analyzed with a source localization technique that enabled voxelwise correlations of EEG and PET data. For theta, but not other bands, the rostral ACC (Brodmann areas 24/32) was the largest cluster with positive correlations between current density and glucose metabolism. Positive correlations were also found in right fronto-temporal regions. In control but not depressed subjects, theta within ACC and prefrontal/orbitofrontal regions was positively correlated. The results reveal a link between theta and cerebral metabolism in the ACC as well as disruption of functional connectivity within frontocingulate pathways in depression.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0048-5772
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
939-49
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:14986847-Adult,
pubmed-meshheading:14986847-Brain Chemistry,
pubmed-meshheading:14986847-Cerebral Cortex,
pubmed-meshheading:14986847-Data Interpretation, Statistical,
pubmed-meshheading:14986847-Depressive Disorder,
pubmed-meshheading:14986847-Electroencephalography,
pubmed-meshheading:14986847-Female,
pubmed-meshheading:14986847-Fluorodeoxyglucose F18,
pubmed-meshheading:14986847-Glucose,
pubmed-meshheading:14986847-Humans,
pubmed-meshheading:14986847-Image Processing, Computer-Assisted,
pubmed-meshheading:14986847-Male,
pubmed-meshheading:14986847-Radiopharmaceuticals,
pubmed-meshheading:14986847-Theta Rhythm,
pubmed-meshheading:14986847-Tomography, Emission-Computed
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pubmed:year |
2003
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pubmed:articleTitle |
Coupling of theta activity and glucose metabolism in the human rostral anterior cingulate cortex: an EEG/PET study of normal and depressed subjects.
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pubmed:affiliation |
Department of Psychology, Harvard University, Cambridge, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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