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pubmed-article:14980684pubmed:abstractTextDevelopment of structure-activity relationship of cyclic guanines I lead us to discovery of a potent and selective series of phosphodiesterase 5 inhibitors 52-59 (IC50=1.3-11.0 nM, PDE6/5=116-600).lld:pubmed
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pubmed-article:14980684pubmed:articleTitleSAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.lld:pubmed
pubmed-article:14980684pubmed:affiliationSchering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. dmitri.pissarnitski@spcorp.comlld:pubmed
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