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14980684
Source:
http://linkedlifedata.com/resource/pubmed/id/14980684
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0018321
,
umls-concept:C0087111
,
umls-concept:C0242350
,
umls-concept:C0243072
,
umls-concept:C0268563
,
umls-concept:C0599894
,
umls-concept:C1318700
,
umls-concept:C1521840
,
umls-concept:C1527148
,
umls-concept:C1880355
pubmed:issue
5
pubmed:dateCreated
2004-2-24
pubmed:abstractText
Development of structure-activity relationship of cyclic guanines I lead us to discovery of a potent and selective series of phosphodiesterase 5 inhibitors 52-59 (IC50=1.3-11.0 nM, PDE6/5=116-600).
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/3',5'-Cyclic-GMP Phosphodiesterases
,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide...
,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine
,
http://linkedlifedata.com/resource/pubmed/chemical/PDE5A protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Polycyclic Compounds
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0960-894X
pubmed:author
pubmed-author:AsberomTheodrosT
,
pubmed-author:BoyleCraig DCD
,
pubmed-author:ChackalamannilSamuelS
,
pubmed-author:ChintalaMadhuM
,
pubmed-author:CladerJohn WJW
,
pubmed-author:GreenleeWilliam JWJ
,
pubmed-author:HuYueqingY
,
pubmed-author:KurowskiStanleyS
,
pubmed-author:MyersJoyceJ
,
pubmed-author:PalamandaJairamJ
,
pubmed-author:PissarnitskiDmitri ADA
,
pubmed-author:StamfordAndrew WAW
,
pubmed-author:TowMM
,
pubmed-author:VemulapalliSubbaraoS
,
pubmed-author:WangPengP
,
pubmed-author:WangYuguangY
,
pubmed-author:WuPingP
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1291-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:14980684-3',5'-Cyclic-GMP Phosphodiesterases
,
pubmed-meshheading:14980684-Cyclic Nucleotide Phosphodiesterases, Type 5
,
pubmed-meshheading:14980684-Drug Delivery Systems
,
pubmed-meshheading:14980684-Erectile Dysfunction
,
pubmed-meshheading:14980684-Guanine
,
pubmed-meshheading:14980684-Humans
,
pubmed-meshheading:14980684-Male
,
pubmed-meshheading:14980684-Phosphodiesterase Inhibitors
,
pubmed-meshheading:14980684-Polycyclic Compounds
,
pubmed-meshheading:14980684-Structure-Activity Relationship
pubmed:year
2004
pubmed:articleTitle
SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.
pubmed:affiliation
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. dmitri.pissarnitski@spcorp.com
pubmed:publicationType
Journal Article