Linked Life Data

14967522

Source:http://linkedlifedata.com/resource/pubmed/id/14967522

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2004-2-17
pubmed:abstractText
The study of nanogel (hydrogel nanoparticle) has intensified in the last decade due to the enormous potential applications in biomimetics, biosensors, artificial muscles and drug delivery (or release) systems. Cholesterol-bearing pullulan (CHP) is composed of hydrophilic pullulan backbone and partly substituted hydrophobic cholesterol, and is capable of forming a stable hydrogel nanoparticle in aqueous solution due to the self-assembly of hydrophobic cholesterol moieties. The conformation of CHP changes dramatically at the hydrophobic interfaces. In order to understand the interfacial responses of CHP, the interaction forces of CHP nanogels to the hydrophobic HOPG (highly orientated pyrolytic graphite) or carbon-coated surfaces were measured using atomic force microscope. The freely jointed china model for CHP molecular elasticity was applied to the force-extension curves and debonding force-pull-off distance in order to estimate the contour lengths and the segment lengths of the CHP molecules. The segment length of CHP chains in aqueous solution was estimated 0.32+/-0.19 nm showing a very flexible chain. From our analysis of the dynamic force measurements, the debonding forces were shown to depend on the applied loading forces. The zero kinetic off-rate K(off)(0) and the transition state x(b) were estimated to be 1.1 x 10(-3)s(-1) and 2.9A, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2911-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Single molecular mechanics of a cholesterol-bearing pullulan nanogel at the hydrophobic interfaces.
pubmed:affiliation
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan. ilee@nankai.edu.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Evaluation Studies