rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
2004-2-17
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pubmed:abstractText |
Cytokines are inflammatory mediators found in the circulation after surgery. Newborns have less protection against oxidation and are very susceptible to free radical oxidative damage. Melatonin has been reported recently to reduce oxidative stress in neonates with sepsis, asphyxia, and respiratory distress. The aim of this study has been to determine if melatonin would lower interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha) and nitrite/nitrate (NOx) levels and modify serum inflammation parameters, improving the clinical course of surgical neonates.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
1531-5037
|
pubmed:author |
pubmed-author:AntonuccioPP,
pubmed-author:BarberiII,
pubmed-author:BasileMM,
pubmed-author:GentileCC,
pubmed-author:GittoEE,
pubmed-author:ImpellizzeriPP,
pubmed-author:PesceSS,
pubmed-author:ReiterR JRJ,
pubmed-author:RomerDD,
pubmed-author:TrimarchiGG,
pubmed-author:ZuccarelloBB
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pubmed:issnType |
Electronic
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pubmed:volume |
39
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
184-9; discussion 184-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14966737-Female,
pubmed-meshheading:14966737-Humans,
pubmed-meshheading:14966737-Infant, Newborn,
pubmed-meshheading:14966737-Infant, Newborn, Diseases,
pubmed-meshheading:14966737-Interleukin-6,
pubmed-meshheading:14966737-Interleukin-8,
pubmed-meshheading:14966737-Male,
pubmed-meshheading:14966737-Melatonin,
pubmed-meshheading:14966737-Nitrates,
pubmed-meshheading:14966737-Nitrites,
pubmed-meshheading:14966737-Oxidative Stress,
pubmed-meshheading:14966737-Postoperative Period,
pubmed-meshheading:14966737-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
Melatonin reduces oxidative stress in surgical neonates.
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pubmed:affiliation |
Department of Medical and Surgical Pediatric Sciences, Neonatal Intensive Care Unit, University of Messina, Messina, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial
|