Source:http://linkedlifedata.com/resource/pubmed/id/14960644
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2004-2-12
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pubmed:abstractText |
Disseminated, metastatic cancer is frequently incurable. Targeted alpha-particle emitters hold great promise as therapeutic agents for disseminated disease. (225)Ac is a radionuclide generator that has a 10-d half-life and results in alpha-emitting daughter elements ((221)Fr, (217)At, (213)Bi) that lead to the emission of a total of 4 alpha-particles. The aim of this study was to develop approaches for stable and controlled targeting of (225)Ac to sites of disseminated tumor metastases. Liposomes with encapsulated (225)Ac were developed to retain the potentially toxic daughters at the tumor site.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0161-5505
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
253-60
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14960644-Actinium,
pubmed-meshheading:14960644-Alpha Particles,
pubmed-meshheading:14960644-Animals,
pubmed-meshheading:14960644-Bismuth,
pubmed-meshheading:14960644-Humans,
pubmed-meshheading:14960644-Liposomes,
pubmed-meshheading:14960644-Microscopy, Electron,
pubmed-meshheading:14960644-Neoplasm Metastasis,
pubmed-meshheading:14960644-Radioisotopes
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pubmed:year |
2004
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pubmed:articleTitle |
Engineered liposomes for potential alpha-particle therapy of metastatic cancer.
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pubmed:affiliation |
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. sofous@mskcc.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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