rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
2004-2-11
|
pubmed:abstractText |
Mutations in the mitochondrial DNA (mtDNA) have been observed frequently in human neoplasia, in both coding and noncoding regions. A mononucleotide repeat (poly-C) between 303 and 315 nucleotides (D310) within the regulatory displacement loop has been identified recently as a frequent hot spot of deletion/insertion mutations in tumors. We investigated the frequency and pattern of D310 abnormalities in the pathogenesis of gallbladder carcinoma (GBC).
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
1078-0432
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
10
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1041-6
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14871983-Aged,
pubmed-meshheading:14871983-Aged, 80 and over,
pubmed-meshheading:14871983-Carcinoma,
pubmed-meshheading:14871983-Cholecystitis,
pubmed-meshheading:14871983-DNA,
pubmed-meshheading:14871983-DNA, Mitochondrial,
pubmed-meshheading:14871983-Female,
pubmed-meshheading:14871983-Gallbladder Neoplasms,
pubmed-meshheading:14871983-Gene Deletion,
pubmed-meshheading:14871983-Genotype,
pubmed-meshheading:14871983-Humans,
pubmed-meshheading:14871983-Male,
pubmed-meshheading:14871983-Middle Aged,
pubmed-meshheading:14871983-Mutation,
pubmed-meshheading:14871983-Neoplasms,
pubmed-meshheading:14871983-Polymerase Chain Reaction,
pubmed-meshheading:14871983-Repetitive Sequences, Nucleic Acid
|
pubmed:year |
2004
|
pubmed:articleTitle |
Mitochondrial DNA mutation at the D310 (displacement loop) mononucleotide sequence in the pathogenesis of gallbladder carcinoma.
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pubmed:affiliation |
Department of Anatomic Pathology, Pontificia Universidad Catolica de Chile, Hospital Dr. Sotero del Rio, Santiago, Chile.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|