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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1993-2-19
|
| pubmed:abstractText |
1. SH-SY5Y, a human neuroblastoma cell line, was used as a tissue culture model to examine the hypothesis that cocaine may affect the metabolism of tau protein which stabilizes microtubules and promotes microtubule assembly. 2. Cocaine hydrochloride (10(-9)-10(-3) M) caused dose-dependent reductions in cell number, with 10(-3) M causing 28% reduction after 48 hr. 3. This drug also decreased tau protein (50 Kd) in the cytoplasmic (supernatant) as well as the membrane (pellet) fraction after 48-hr treatment.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0306-3623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1111-3
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1487120-Blotting, Western,
pubmed-meshheading:1487120-Brain Neoplasms,
pubmed-meshheading:1487120-Cocaine,
pubmed-meshheading:1487120-Cytoplasm,
pubmed-meshheading:1487120-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:1487120-Humans,
pubmed-meshheading:1487120-Microtubules,
pubmed-meshheading:1487120-Neuroblastoma,
pubmed-meshheading:1487120-Tumor Cells, Cultured,
pubmed-meshheading:1487120-tau Proteins
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Microtubular tau protein after cocaine in cultured SH-SY5Y human neuroblastoma.
|
| pubmed:affiliation |
Department of Anatomy, College of Human Medicine, Michigan State University, E. Lansing 48824.
|
| pubmed:publicationType |
Journal Article
|