Linked Life Data

1486565

Source:http://linkedlifedata.com/resource/pubmed/id/1486565

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-2-25
pubmed:abstractText
Cytogenetic analysis of eight ultraviolet radiation (UVR)-induced cutaneous tumors and one spontaneously transformed fibroblast cell line of Monodelphis domestica showed that two of the tumor cell lines were of murine origin and that the remaining six marsupial tumor cell lines had hyperdiploid stemline numbers ranging from 21 to 31. Each tumor cell line showed structural and numerical abnormalities. The single transformed fibroblast cell line also showed a hyperdiploid chromosome number with structural and numerical defects. All M. domestica tumor cell lines and the fibroblast line showed a common structural abnormality: deletion of the short arm (p) of a chromosome 1. In some cell lines, the short arm of chromosome 1 was replaced by a translocation with the X chromosome. We suggest, based on the Giemsa-banding homology of chromosome 1p in M. domestica and human chromosome 6q involved in melanomas, that marsupial chromosome 1p may harbor tumor suppressor gene(s) that are associated with UVR-induced cutaneous tumors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0165-4608
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
158-62
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Specific chromosomal defects associated with ultraviolet radiation-induced cutaneous tumors in Monodelphis domestica (Marsupialia, mammalia).
pubmed:affiliation
Department of Cell Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't