Linked Life Data

1478335

Source:http://linkedlifedata.com/resource/pubmed/id/1478335

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1993-2-11
pubmed:abstractText
This overview summarizes the properties and mechanism of retroviral DNA integration and the consequences of the integration process to the infected cell and host. Integration of viral into cellular DNA is a regular and irreversible event, essential for virus replication, whose mechanism is becoming well understood. Many pathogenic consequences of retrovirus infection are due to side-effects of the integration process, including gene disruption, activation of proto-oncogenes, acquisition of oncogenes, and inappropriate expression of viral gene products. The properties and risks associated with these events are reviewed along with overall conclusions as to the importance of these to possible retroviral contaminants of biologicals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-5149
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-51
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Retroviral DNA integration.
pubmed:affiliation
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
pubmed:publicationType
Journal Article, Review