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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1993-2-5
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pubmed:abstractText |
The use of empirical antimicrobial therapy has significantly reduced the morbidity and mortality associated with untreated infections in febrile neutropenic patients. This guideline describes clinical trials of the safety and efficacy of new antimicrobial drugs in this population of patients. Fever and neutropenia should be precisely defined in each protocol. Patients should be randomized to treatment with a new or active-control drug regimen, stratified on the basis of type of cancer and age, and treated until resolution--as defined in the protocol--is attained. Outcome should be assessed both for cases with a defined microbial etiology and for those without. Final microbiological outcome is important for cases with identified pathogens, but clinical outcome is paramount.
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pubmed:grant | |
pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1058-4838
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
15 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S206-15
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1477232-Anti-Infective Agents,
pubmed-meshheading:1477232-Clinical Protocols,
pubmed-meshheading:1477232-Clinical Trials, Phase I as Topic,
pubmed-meshheading:1477232-Clinical Trials, Phase II as Topic,
pubmed-meshheading:1477232-Clinical Trials, Phase III as Topic,
pubmed-meshheading:1477232-Clinical Trials as Topic,
pubmed-meshheading:1477232-Fever,
pubmed-meshheading:1477232-Humans,
pubmed-meshheading:1477232-Infection,
pubmed-meshheading:1477232-Neutropenia,
pubmed-meshheading:1477232-Research Design
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pubmed:year |
1992
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pubmed:articleTitle |
Evaluation of new anti-infective drugs for the treatment of febrile episodes in neutropenic patients. Infectious Diseases Society of America and the Food and Drug Administration.
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pubmed:affiliation |
Division of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
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pubmed:publicationType |
Journal Article,
Guideline,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Practice Guideline
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