Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-3-23
pubmed:abstractText
Human immunodeficiency virus type 1 (HIV-1) Vpr is a 15-kDa accessory protein that contributes to several steps in the viral replication cycle and promotes virus-associated pathology. Previous studies demonstrated that Vpr inhibits G2/M cell cycle progression in both human cells and in the fission yeast Schizosaccharomyces pombe. Here, we report that, upon induction of vpr expression, fission yeast exhibited numerous defects in the assembly and function of the mitotic spindle. In particular, two spindle pole body proteins, sad1p and the polo kinase plo1p, were delocalized in vpr-expressing yeast cells, suggesting that spindle pole body integrity was perturbed. In addition, nuclear envelope structure, contractile actin ring formation, and cytokinesis were also disrupted. Similar Vpr-induced defects in mitosis and cytokinesis were observed in human cells, including aberrant mitotic spindles, multiple centrosomes, and multinucleate cells. These defects in cell division and centrosomes might account for some of the pathological effects associated with HIV-1 infection.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-10022828, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-10074177, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-10684278, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-10713718, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-10896777, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-10921875, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-10944189, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-10958988, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11086011, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11222860, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11231572, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11239388, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11264352, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11285289, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11331889, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11531413, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11559813, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11691994, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11714748, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11792542, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-11847097, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-12356862, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-12367754, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-12417576, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-12446769, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-1324171, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-2139896, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-2150318, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-2186047, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-2606940, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-7474080, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-7474100, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-7531918, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-7666531, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-7744248, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-7744953, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-7815556, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-7877997, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-8041786, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-8230445, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-8422996, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-8642659, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-8709199, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-8834798, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-9126266, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-9427608, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-9436978, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-9463369, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-9657945, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-9837715, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-9852154, http://linkedlifedata.com/resource/pubmed/commentcorrection/14767062-9869630
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1059-1524
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1793-801
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...