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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-2-9
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pubmed:abstractText |
A total of 76 patients discontinued treatment with didanosine plus hydroxyurea after 1 year of maintenance therapy. The greatest human immunodeficiency virus (HIV)-RNA rebounds were seen in 10 patients harboring an L74V mutation, and the presence of viruses with this mutation rapidly waned. In contrast, viral rebounds were significantly less pronounced (P < 0.01) in 12 subjects harboring thymidine-associated mutations; these mutations persisted in all instances. Thus, selection of an L74V mutation during didanosine therapy may compromise HIV replication in vivo.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-10482597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-10601505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-10634336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-10634339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-10708295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-10722492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-10877738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-11172188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-11416735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-11588505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-11919491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-12095387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-12210423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-12368352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-12370421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-12370434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-12441810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-12830416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-12837968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-7506280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-7969058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-8103317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-9343245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-9359660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14766874-9683207
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
862-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:14766874-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:14766874-Amino Acid Substitution,
pubmed-meshheading:14766874-Anti-HIV Agents,
pubmed-meshheading:14766874-CD4 Lymphocyte Count,
pubmed-meshheading:14766874-Didanosine,
pubmed-meshheading:14766874-Female,
pubmed-meshheading:14766874-Genotype,
pubmed-meshheading:14766874-HIV,
pubmed-meshheading:14766874-Humans,
pubmed-meshheading:14766874-Hydroxyurea,
pubmed-meshheading:14766874-Male,
pubmed-meshheading:14766874-Mutagenesis, Site-Directed,
pubmed-meshheading:14766874-Mutation,
pubmed-meshheading:14766874-RNA, Viral,
pubmed-meshheading:14766874-Thymidine,
pubmed-meshheading:14766874-Time Factors,
pubmed-meshheading:14766874-Viral Load
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pubmed:year |
2004
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pubmed:articleTitle |
Different viral rebound following discontinuation of antiretroviral therapy in cases of infection with viruses carrying L74V or thymidine-associated mutations.
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pubmed:affiliation |
Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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