Source:http://linkedlifedata.com/resource/pubmed/id/14759592
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2004-2-4
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| pubmed:abstractText |
Antioxidants protect cells from oxidative damage and reduce lipopolysaccharide (LPS)-induced expression of inflammatory cytokines. Because inflammatory cytokines induce sickness behavior, we hypothesized that antioxidants, namely alpha-tocopherol (alpha-T) and selenium would inhibit sickness behavior caused by LPS. In an initial study, mice were injected intraperitoneal (i.p.) with vehicle, 2, or 20mg alpha-T for 3 consecutive days and then challenged with vehicle, 1, 10, or 100 microg of LPS. Sickness behavior was quantified by measuring social exploratory behavior. Vehicle pretreated mice injected with LPS showed a marked reduction in social behavior at 4h (p < .01). However, sickness behavior induced by the lowest dose of LPS was partially or completely blocked by 2 or 20mg alpha-T, respectively. alpha-T did not prevent sickness from higher doses of LPS. In a second study, mice were fed AIN93-M modified diets containing 10, 75, and 500 mg alpha-T/kg and 0.05, 0.15, and 2mg selenium/kg for 8 weeks and then challenged with saline or LPS (1 microg). The highest concentration of dietary alpha-T and selenium tended (p = .1) to reduce LPS-induced sickness behavior. Mice fed diets low in antioxidants had reduced plasma alpha-T levels and glutathione peroxidase activity (p = .08 and p < .01, respectively) and elevated liver thiobarbituric acid reactive substances (p < .001) 24h post LPS. Collectively, these data indicate that alpha-T improved the oxidative status after exposure to LPS, which may explain its ability to ameliorate symptoms of sickness.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Selenium,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Tocopherol
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0889-1591
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
149-57
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:14759592-Analysis of Variance,
pubmed-meshheading:14759592-Animal Feed,
pubmed-meshheading:14759592-Animals,
pubmed-meshheading:14759592-Antioxidants,
pubmed-meshheading:14759592-Behavior, Animal,
pubmed-meshheading:14759592-Dietary Supplements,
pubmed-meshheading:14759592-Dose-Response Relationship, Drug,
pubmed-meshheading:14759592-Drug Synergism,
pubmed-meshheading:14759592-Exploratory Behavior,
pubmed-meshheading:14759592-Glutathione Peroxidase,
pubmed-meshheading:14759592-Lipid Peroxidation,
pubmed-meshheading:14759592-Lipopolysaccharides,
pubmed-meshheading:14759592-Male,
pubmed-meshheading:14759592-Mice,
pubmed-meshheading:14759592-Mice, Inbred BALB C,
pubmed-meshheading:14759592-Selenium,
pubmed-meshheading:14759592-Social Behavior,
pubmed-meshheading:14759592-alpha-Tocopherol
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| pubmed:year |
2004
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| pubmed:articleTitle |
Alpha-tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice.
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| pubmed:affiliation |
Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|