Linked Life Data

14757319

Source:http://linkedlifedata.com/resource/pubmed/id/14757319

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-2-3
pubmed:abstractText
The ability of dimethyl sulfoxide (DMSO) to induce the acute-phase (AP) response was examined. Injection of DMSO to laboratory rats caused a rapid doubling of the plasma corticosterone concentration 2 h after treatment. The elevated corticosterone concentration promoted the synthesis of mRNAs for several AP reactants. At 24 h after DMSO administration the relative serum concentration of cysteine-proteinase inhibitor (CPI) increased about 710%, alpha1-acid glycoprotein (AGP) 630%, alpha1-macroglobulin (MG) 510%, gamma fibrinogen (Fb) 420%, haptoglobin (Hp) 280%, whereas the relative concentration of albumin, a "negative" AP reactant, decreased to 93%. The extent and kinetics of the corticosterone increase and the general increase of AP reactant mRNAs and protein serum concentrations after DMSO administration corresponded to the overall changes observed during the turpentine-induced AP response. On the basis of these findings it was concluded that DMSO was capable of promoting the AP response in rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0378-4274
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
147
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Acute-phase protein expression in DMSO-intoxicated rats.
pubmed:affiliation
Molecular Biology Laboratory, Institute for Biological Research, 29th November, 11060 Belgrade, Serbia and Montenegro.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't