|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2004-2-4
|
|
pubmed:abstractText |
To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1078-8956
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
143-5
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:14745442-Animals,
pubmed-meshheading:14745442-Autopsy,
pubmed-meshheading:14745442-Brain,
pubmed-meshheading:14745442-Capillaries,
pubmed-meshheading:14745442-Cause of Death,
pubmed-meshheading:14745442-Cerebrovascular Circulation,
pubmed-meshheading:14745442-Child,
pubmed-meshheading:14745442-Coma,
pubmed-meshheading:14745442-Humans,
pubmed-meshheading:14745442-Malaria, Cerebral,
pubmed-meshheading:14745442-Plasmodium falciparum
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Differentiating the pathologies of cerebral malaria by postmortem parasite counts.
|
|
pubmed:affiliation |
Department of Internal Medicine, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan 48824, USA. taylort@msu.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
