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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-1-26
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pubmed:abstractText |
The common polymorphism at codon 311 (C311S) of paraoxonase 2 gene (PON2) was investigated in 165 patients with sporadic late-onset Alzheimer's disease (LOAD) and 174 controls in Chinese. The PON2*C allele frequency was significantly increased in the patients as compared with controls. However, no significant difference was observed after stratification of apolipoprotein E (ApoE) epsilon4 allele. These results suggested that the PON2 polymorphism might be a risk factor for LOAD independent of ApoE epsilon4 status in Chinese.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0169-328X
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pubmed:author |
pubmed-author:BaiII,
pubmed-author:GILGG,
pubmed-author:GuoYangboY,
pubmed-author:HanHaiyingH,
pubmed-author:LiuXieheX,
pubmed-author:ShiJiajunJ,
pubmed-author:TangMouniM,
pubmed-author:TaoLiL,
pubmed-author:WangYingchengY,
pubmed-author:ZhangSizhongS,
pubmed-author:ZhaoJinghuaJ
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14741412-Aged,
pubmed-meshheading:14741412-Aged, 80 and over,
pubmed-meshheading:14741412-Alleles,
pubmed-meshheading:14741412-Alzheimer Disease,
pubmed-meshheading:14741412-Apolipoproteins E,
pubmed-meshheading:14741412-Aryldialkylphosphatase,
pubmed-meshheading:14741412-Asian Continental Ancestry Group,
pubmed-meshheading:14741412-Chi-Square Distribution,
pubmed-meshheading:14741412-Cysteine,
pubmed-meshheading:14741412-Female,
pubmed-meshheading:14741412-Gene Frequency,
pubmed-meshheading:14741412-Genetic Predisposition to Disease,
pubmed-meshheading:14741412-Genotype,
pubmed-meshheading:14741412-Humans,
pubmed-meshheading:14741412-Male,
pubmed-meshheading:14741412-Polymerase Chain Reaction,
pubmed-meshheading:14741412-Polymorphism, Genetic,
pubmed-meshheading:14741412-Serine
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pubmed:year |
2004
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pubmed:articleTitle |
Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese.
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pubmed:affiliation |
Key Laboratory of Biotherapy of Human Diseases, Department of Medical Genetics, West China Hospital and Division of Human Morbid Genomics, Ministry of Education, Sichuan University, Chengdu, 610041, China. szzhang@mcwcums.com
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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