Source:http://linkedlifedata.com/resource/pubmed/id/14740279
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2004-1-23
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| pubmed:abstractText |
We investigated the use, in a short period, of Humalog Mix25 (Mix25) in a twice-daily administration regimen compared to a twice-daily injection therapy with Humulin 30/70 (30/70) in diabetic patients with Italian dietary habits. We studied 33 type 2 diabetic patients aged 59.1 +/- 8.1 years, BMI 29.8 +/- 2.7 kg/m2, duration of diabetes and insulin therapy of 14.4 +/- 9.8 and 4.2 +/- 4.6 years, respectively. After a 4-day lead-in period of twice-daily human insulin 30/70 treatment, patients were randomized to one of two treatment sequences: (1) a twice-daily regimen with Mix25 just 5 minutes before the morning and evening meals for 12 days, followed by a twice-daily therapy with human insulin 30/70 given 30 minutes before the morning and evening meals for an additional 12 days; or (2) the alternate sequence. Each patient underwent a mixed meal test: Humulin 30/70 was administered 30 minutes before the meal, while Mix25 was given 5 minutes before. The 2-hour post-prandial glucose concentration after breakfast was significantly lower during treatment with Mix25 than with Humulin 30/70 (157 +/- 43.2 vs. 180 +/- 43.2 mg/dl, p<0.05). The glycemic excursion after dinner on Mix25 treatment was significantly lower than with Humulin 30/70 (12.2 +/- 48.01 vs. 35.5 +/- 36.92 mg/dl, p<0.05). AUCglucose after Mix25 was lower than after Humulin 30/70. Glycemia after test meal was significantly lower with Mix25 than with Humulin 30/70. Insulin and free insulin concentrations after the test meal were significantly higher with Mix25 in comparison to Humulin 30/70. AUC serum insulin and free insulin curves after Mix25 were significantly higher than after Humulin 30/70 (p=0.028 and p=0.005, respectively). Twice-daily injections of Humalog Mix25, compared to human insulin 30/70 in type 2 diabetic patients with Italian dietary habits, provide improved and lasting post-prandial glycemic control, with the great convenience of the injection just before the meal.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biphasic Insulins,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin, Isophane,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Lispro
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0940-5429
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| pubmed:author |
pubmed-author:CalderiniCC,
pubmed-author:CamporealeAA,
pubmed-author:CarleoRR,
pubmed-author:CasalePP,
pubmed-author:CoscelliCC,
pubmed-author:Di MarioUU,
pubmed-author:FalcelliCC,
pubmed-author:GalluzzoAA,
pubmed-author:GobboMM,
pubmed-author:IacobellisGG,
pubmed-author:LeonettiFF,
pubmed-author:LunettaMM,
pubmed-author:MeranteDD,
pubmed-author:PaleariFF,
pubmed-author:PirroneVV,
pubmed-author:ValleDD
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| pubmed:issnType |
Print
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| pubmed:volume |
40
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
187-92
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:14740279-Biphasic Insulins,
pubmed-meshheading:14740279-Cross-Over Studies,
pubmed-meshheading:14740279-Diabetes Mellitus, Type 1,
pubmed-meshheading:14740279-Diabetes Mellitus, Type 2,
pubmed-meshheading:14740279-Drug Administration Schedule,
pubmed-meshheading:14740279-Eating,
pubmed-meshheading:14740279-Female,
pubmed-meshheading:14740279-Food Habits,
pubmed-meshheading:14740279-Humans,
pubmed-meshheading:14740279-Hypoglycemic Agents,
pubmed-meshheading:14740279-Injections, Subcutaneous,
pubmed-meshheading:14740279-Insulin,
pubmed-meshheading:14740279-Insulin, Isophane,
pubmed-meshheading:14740279-Insulin Lispro,
pubmed-meshheading:14740279-Italy,
pubmed-meshheading:14740279-Male,
pubmed-meshheading:14740279-Middle Aged,
pubmed-meshheading:14740279-Research Design,
pubmed-meshheading:14740279-Time Factors
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| pubmed:year |
2003
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| pubmed:articleTitle |
Importance of premeal injection time in insulin therapy: Humalog Mix25 is convenient for improved post-prandial glycemic control in type 2 diabetic patients with Italian dietary habits.
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| pubmed:affiliation |
Department of Internal Medicine and Metabolic Diseases, Parma Hospital, Parma, Italy.
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|