| pubmed-article:14736249 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14736249 | lifeskim:mentions | umls-concept:C0025250 | lld:lifeskim |
| pubmed-article:14736249 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:14736249 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:14736249 | lifeskim:mentions | umls-concept:C1824378 | lld:lifeskim |
| pubmed-article:14736249 | lifeskim:mentions | umls-concept:C0439810 | lld:lifeskim |
| pubmed-article:14736249 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:14736249 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:14736249 | lifeskim:mentions | umls-concept:C0383507 | lld:lifeskim |
| pubmed-article:14736249 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14736249 | pubmed:dateCreated | 2004-1-22 | lld:pubmed |
| pubmed-article:14736249 | pubmed:abstractText | The unsubstituted, 3'-Cl, 4'-C1, and 3',4'-diCl C10 analogues of cryptophycin-24 were prepared via total synthesis and tested in vitro for cytotoxicity against MCF-7 and multi-drug-resistant MCF-7/ADR breast cancer cell lines and in a tubulin assembly assay. The ED(50) values ranged from 7.2 to 15.8 microM in the tubulin assay and from 0.05 to 3.4 nM in the cell assays. The presence of a 3'-C1 and/or 4'-C1 substituent on the C10 phenyl ring increased cytotoxicity in the MCF-7 cell line compared to the unsubstituted phenyl ring. The most potent compound in this series possessed a 3'-C1 substituent on the C10 phenyl ring. The 3'-C1 analogue had ED(50) values of 50 and 580 pM in the MCF-7 and MCF-7/ADR cell lines, respectively. Its activity was very similar to the parent compound cryptophycin-24. Substitution of the 4'-MeO group in cryptophycin-24 with a 4'-C1 moiety did not significantly affect cytotoxicity against MCF-7 and MCF-7/ADR cells compared to the parent compound. These results demonstrated that the 4'-MeO group in cryptophycin-24 is not essential and can be replaced with 3'-C1 or 4'-C1 substituents. | lld:pubmed |
| pubmed-article:14736249 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14736249 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14736249 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14736249 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14736249 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14736249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14736249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14736249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14736249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14736249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14736249 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14736249 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14736249 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:14736249 | pubmed:author | pubmed-author:GeorgGunda... | lld:pubmed |
| pubmed-article:14736249 | pubmed:author | pubmed-author:HimesRichard... | lld:pubmed |
| pubmed-article:14736249 | pubmed:author | pubmed-author:HuffJacquelyn... | lld:pubmed |
| pubmed-article:14736249 | pubmed:author | pubmed-author:BuckSuzanne... | lld:pubmed |
| pubmed-article:14736249 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14736249 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:14736249 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:14736249 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14736249 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14736249 | pubmed:pagination | 696-702 | lld:pubmed |
| pubmed-article:14736249 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:14736249 | pubmed:meshHeading | pubmed-meshheading:14736249... | lld:pubmed |
| pubmed-article:14736249 | pubmed:meshHeading | pubmed-meshheading:14736249... | lld:pubmed |
| pubmed-article:14736249 | pubmed:meshHeading | pubmed-meshheading:14736249... | lld:pubmed |
| pubmed-article:14736249 | pubmed:meshHeading | pubmed-meshheading:14736249... | lld:pubmed |
| pubmed-article:14736249 | pubmed:meshHeading | pubmed-meshheading:14736249... | lld:pubmed |
| pubmed-article:14736249 | pubmed:meshHeading | pubmed-meshheading:14736249... | lld:pubmed |
| pubmed-article:14736249 | pubmed:meshHeading | pubmed-meshheading:14736249... | lld:pubmed |
| pubmed-article:14736249 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14736249 | pubmed:articleTitle | Total synthesis and antitubulin activity of c10 analogues of cryptophycin-24. | lld:pubmed |
| pubmed-article:14736249 | pubmed:affiliation | Department of Medicinal Chemistry and Department of Molecular Biosciences, University of Kansas, 1251 Wescoe Drive, Lawrence, Kansas 66045-7582, USA. | lld:pubmed |
| pubmed-article:14736249 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14736249 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14736249 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:14736249 | lld:chembl |
