|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0010097,
umls-concept:C0013030,
umls-concept:C0025519,
umls-concept:C0028351,
umls-concept:C0030685,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0162512,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1515655,
umls-concept:C1709634,
umls-concept:C1963578
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|
pubmed:issue |
11-12
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|
pubmed:dateCreated |
1993-1-29
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|
pubmed:abstractText |
The effect of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) on dopamine (DA) release and metabolism in the striatum was studied in freely moving rats by intracerebral microdialysis techniques. The DA level as well as the levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly decreased 140 min after the administration of L-threo-DOPS (50 mg/kg intraperitoneally). The results suggest that L-threo-DOPS inhibits the release and metabolism of DA in the striatum.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Dec
|
|
pubmed:issn |
0014-4754
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
1
|
|
pubmed:volume |
48
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1133-4
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|
pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
|
|
pubmed:year |
1992
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|
pubmed:articleTitle |
L-threo-3,4-dihydroxyphenylserine, a noradrenaline precursor, inhibits dopamine release and metabolism in the rat striatum in vivo.
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|
pubmed:affiliation |
Department of Pharmacology, Kurume University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
|
