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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0013081,
umls-concept:C0017337,
umls-concept:C0022378,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0034678,
umls-concept:C0043342,
umls-concept:C0086376,
umls-concept:C0086418,
umls-concept:C0205314,
umls-concept:C0679058,
umls-concept:C0679622,
umls-concept:C0680022,
umls-concept:C1547699,
umls-concept:C1883220,
umls-concept:C2700640
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|
pubmed:issue |
2
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|
pubmed:dateCreated |
2004-1-20
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|
pubmed:abstractText |
Interstitial cells of Cajal (ICC) are pacemakers and mediators of neurotransmission in gastroenteric smooth muscles. Interstitial cells of Cajal require cellular signaling via KIT, a receptor tyrosine kinase, for development and maintenance of cellular phenotype. Much of the evidence demonstrating the functions of ICC comes from studies of W/W V mutant mice, which have reduced KIT function. The aim of the present study was to differentially examine gene expression in the small intestines of wild-type and W/W V mice.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0815-9319
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
19
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14731133-Animals,
pubmed-meshheading:14731133-GTP Phosphohydrolases,
pubmed-meshheading:14731133-GTP-Binding Proteins,
pubmed-meshheading:14731133-Gastrointestinal Motility,
pubmed-meshheading:14731133-Gene Expression Profiling,
pubmed-meshheading:14731133-Humans,
pubmed-meshheading:14731133-Jejunum,
pubmed-meshheading:14731133-Mice,
pubmed-meshheading:14731133-Mice, Mutant Strains,
pubmed-meshheading:14731133-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:14731133-Proto-Oncogene Proteins p21(ras),
pubmed-meshheading:14731133-RNA, Messenger,
pubmed-meshheading:14731133-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:14731133-Sequence Analysis, DNA,
pubmed-meshheading:14731133-Sequence Homology,
pubmed-meshheading:14731133-Starvation,
pubmed-meshheading:14731133-Xenopus,
pubmed-meshheading:14731133-cdc42 GTP-Binding Protein
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pubmed:year |
2004
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pubmed:articleTitle |
Novel human, mouse and xenopus genes encoding a member of the RAS superfamily of low-molecular-weight GTP-binding proteins and its downregulation in W/WV mouse jejunum.
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pubmed:affiliation |
Department of Medicine, University of Yamanashi School of Medicine, Yamanashi, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
