Linked Life Data

14727458

Source:http://linkedlifedata.com/resource/pubmed/id/14727458

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4 Suppl 30
pubmed:dateCreated
2004-1-19
pubmed:abstractText
A young patient with familial Mediterranean fever (FMF) developed leukopenia each time she took colchicine. However, when she discontinued the drug the white cell and the platelets counts increased but she experienced FMF attacks. Later it was found that the patient also had concomitant cytomegalovirus (CMV) infection. This complex situation posed several diagnostic and therapeutic issues concerning the real cause for the leukopenia and the possible approach to take in such conditions. We propose that when an essential drug (such as colchicine for FMF) causes leukopenia, one should look for concurrent CMV or another viral infection. If there is no such infection, it is suggested that the mechanism leading to leukopenia be clarified. In the case of bone marrow suppression, colchicine should be continued with injections of G-CSF, whereas if the bone marrow is hypercellular it is suggested to use steroids and colchicine concomitantly.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0392-856X
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S38-40
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Colchicine-induced leukopenia in a patient with familial Mediterranean fever: the cause and a possible approach.
pubmed:affiliation
Department of Medicine, Hadassah University Hospital, Jerusalem, POB12000, Israel. eldad@hadassah.org.il
pubmed:publicationType
Journal Article, Case Reports