Linked Life Data

147268

Source:http://linkedlifedata.com/resource/pubmed/id/147268

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-5-17
pubmed:abstractText
Tetrabenazine (Nitoman, Roche) is a synthetic benzoquinolizine derivative which resembles reserpine pharmacologically and depletes dopamine and other monoamines in the central nervous system. Considerable evidence has now been accumulated regarding the physiologic equilibrium which exists between dopamine and acetylcholine in the human striatum and it appears that dopamine excess or dopaminergic receptor supersensitivity are mechanisms operating in hyperkinetic disorders like Huntington's Chorea. The treatment of hyperkinetic disorders by dopamine depleting agents, like tetrabenazine or reserpine, or by dopamine blocking agents, like Haloperidol and Pimozide, has not been tried for more than a decade. We report here our own observations in 15 patients with various hyperkinetic disorders treated with tetrabenazine in doses up to 200 mgm. daily for periods up to 12 months.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0160-6689
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Tetrabenazine in the treatment of Huntington's chorea and other hyperkinetic movement disorders.
pubmed:publicationType
Journal Article