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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-1-13
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pubmed:abstractText |
The molecular basis of host-tumor interaction in HLA-A31+ cancer patients has not been well understood. This lack of clarification is hampering the development of specific immunotherapies for these patients. This study aimed to identify a set of CTL-epitope peptides applicable for the specific immunotherapy of cancer patients with HLA-A31 allele. HLA-A31 allele is expressed in 5-10% of the world population, with the highest expression among Brazilian Amerinds (65%), and the lowest in the Eskimo population (0%). We report herein four cDNAs encoding CTL-epitopes and 7 epitope peptides with the ability to induce HLA-A31-restricted CTLs cytotoxic to tumor cell lines in the peripheral blood mononuclear cells of HLA-A31+ cancer patients. These peptides might be useful for the development of a peptide-based immunotherapy for HLA-A31+ cancer patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Cancer Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A31 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Subunit
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1019-6439
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
337-47
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:14719110-Alleles,
pubmed-meshheading:14719110-Amino Acid Sequence,
pubmed-meshheading:14719110-Animals,
pubmed-meshheading:14719110-Antigens, Neoplasm,
pubmed-meshheading:14719110-Blotting, Northern,
pubmed-meshheading:14719110-COS Cells,
pubmed-meshheading:14719110-Cancer Vaccines,
pubmed-meshheading:14719110-Cell Line, Tumor,
pubmed-meshheading:14719110-DNA, Complementary,
pubmed-meshheading:14719110-Dose-Response Relationship, Drug,
pubmed-meshheading:14719110-Epitopes,
pubmed-meshheading:14719110-Epitopes, T-Lymphocyte,
pubmed-meshheading:14719110-HLA-A Antigens,
pubmed-meshheading:14719110-Humans,
pubmed-meshheading:14719110-Immunotherapy,
pubmed-meshheading:14719110-Leukocytes, Mononuclear,
pubmed-meshheading:14719110-Molecular Sequence Data,
pubmed-meshheading:14719110-Neoplasms, Glandular and Epithelial,
pubmed-meshheading:14719110-Peptides,
pubmed-meshheading:14719110-RNA, Messenger,
pubmed-meshheading:14719110-Sequence Homology, Amino Acid,
pubmed-meshheading:14719110-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:14719110-Vaccines, Subunit
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pubmed:year |
2004
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pubmed:articleTitle |
Detection of a set of peptide vaccine candidates for use in HLA-A31+ epithelial cancer patients.
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pubmed:affiliation |
Department of Immunology, Kurume University School of Medicine, Kurume, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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