| pubmed-article:14712275 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14712275 | lifeskim:mentions | umls-concept:C0024204 | lld:lifeskim |
| pubmed-article:14712275 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:14712275 | lifeskim:mentions | umls-concept:C1709305 | lld:lifeskim |
| pubmed-article:14712275 | lifeskim:mentions | umls-concept:C0585064 | lld:lifeskim |
| pubmed-article:14712275 | pubmed:issue | 6970 | lld:pubmed |
| pubmed-article:14712275 | pubmed:dateCreated | 2004-1-8 | lld:pubmed |
| pubmed-article:14712275 | pubmed:abstractText | Primary T-cell responses in lymph nodes (LNs) require contact-dependent information exchange between T cells and dendritic cells (DCs). Because lymphocytes continually enter and leave normal LNs, the resident lymphocyte pool is composed of non-synchronized cells with different dwell times that display heterogeneous behaviour in mouse LNs in vitro. Here we employ two-photon microscopy in vivo to study antigen-presenting DCs and naive T cells whose dwell time in LNs was synchronized. During the first 8 h after entering from the blood, T cells underwent multiple short encounters with DCs, progressively decreased their motility, and upregulated activation markers. During the subsequent 12 h T cells formed long-lasting stable conjugates with DCs and began to secrete interleukin-2 and interferon-gamma. On the second day, coinciding with the onset of proliferation, T cells resumed their rapid migration and short DC contacts. Thus, T-cell priming by DCs occurs in three successive stages: transient serial encounters during the first activation phase are followed by a second phase of stable contacts culminating in cytokine production, which makes a transition into a third phase of high motility and rapid proliferation. | lld:pubmed |
| pubmed-article:14712275 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14712275 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14712275 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14712275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14712275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14712275 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14712275 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14712275 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:14712275 | pubmed:author | pubmed-author:Von... | lld:pubmed |
| pubmed-article:14712275 | pubmed:author | pubmed-author:HenricksonSar... | lld:pubmed |
| pubmed-article:14712275 | pubmed:author | pubmed-author:MempelThorste... | lld:pubmed |
| pubmed-article:14712275 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:14712275 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:14712275 | pubmed:volume | 427 | lld:pubmed |
| pubmed-article:14712275 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14712275 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14712275 | pubmed:pagination | 154-9 | lld:pubmed |
| pubmed-article:14712275 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:14712275 | pubmed:meshHeading | pubmed-meshheading:14712275... | lld:pubmed |
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| pubmed-article:14712275 | pubmed:meshHeading | pubmed-meshheading:14712275... | lld:pubmed |
| pubmed-article:14712275 | pubmed:meshHeading | pubmed-meshheading:14712275... | lld:pubmed |
| pubmed-article:14712275 | pubmed:meshHeading | pubmed-meshheading:14712275... | lld:pubmed |
| pubmed-article:14712275 | pubmed:meshHeading | pubmed-meshheading:14712275... | lld:pubmed |
| pubmed-article:14712275 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14712275 | pubmed:articleTitle | T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. | lld:pubmed |
| pubmed-article:14712275 | pubmed:affiliation | The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA. | lld:pubmed |
| pubmed-article:14712275 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14712275 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14712275 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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