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pubmed:abstractText |
Compounds 9 and 13 were synthesized, and their structures and stereochemistry were elucidated by spectroscopic methods. In competition binding experiments, specific [(3)H]-PGE(2) binding was significantly displaced by compound 9 and, to a lesser extent, by 13, in a dose-dependent manner. The biological properties of compound 9 were studied on HL-60 cells, and several effects were found related to those of PGE(2). Compound 9 increases c-fos mRNA level as does PGE(2) and antagonizes TPA-induced terminal differentiation.
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pubmed:affiliation |
Instituto Universitario de Bio-Orgánica Antonio González-Instituto de Productos Naturales y Agrobiología-CSIC, Avenida Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Canary Islands, Spain.
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