Source:http://linkedlifedata.com/resource/pubmed/id/14700598
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2003-12-31
|
| pubmed:abstractText |
Polymerase chain reaction-sequence-specific oligonucleotide probes typing methods have been applied to 1000 individuals from the Northern Ireland population to give human leukocyte antigen DRB1 (HLA-DRB1) allele assignment. HLA-DRB1 allele frequencies and four-locus haplotypes (A/B/C/DR) for this Caucasian population, based on HLA class I and class II allele assignment, are now presented. No significant deviations from Hardy-Weinberg proportions were observed. The HLA-C locus exhibited marginal evidence of selection (p<0.03, uncorrected one-sided test) in the direction of balancing selection; the HLA-A, -B, and -DRB1 allele frequency distributions were compatible with expectations under a neutral model (which does not mean that selection is not operating). Evidence for selection was seen on haplotypes HLA-A*010101-B*0801-DRB1*030101 and HLA-A*290201-B*440301-DRB1*070101 based on their patterns of linkage disequilibrium.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0198-8859
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
65
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
66-77
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:14700598-Alleles,
pubmed-meshheading:14700598-Codon,
pubmed-meshheading:14700598-England,
pubmed-meshheading:14700598-Ethnic Groups,
pubmed-meshheading:14700598-European Continental Ancestry Group,
pubmed-meshheading:14700598-Gene Frequency,
pubmed-meshheading:14700598-Genes, MHC Class II,
pubmed-meshheading:14700598-HLA-DR Antigens,
pubmed-meshheading:14700598-HLA-DRB1 Chains,
pubmed-meshheading:14700598-Histocompatibility Testing,
pubmed-meshheading:14700598-Humans,
pubmed-meshheading:14700598-Linkage Disequilibrium,
pubmed-meshheading:14700598-Luminescent Measurements,
pubmed-meshheading:14700598-Models, Genetic,
pubmed-meshheading:14700598-Northern Ireland,
pubmed-meshheading:14700598-Oligonucleotide Probes,
pubmed-meshheading:14700598-Polymerase Chain Reaction,
pubmed-meshheading:14700598-Scotland
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
High resolution HLA-DRB1 identification of a Caucasian population.
|
| pubmed:affiliation |
Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland. fionnuala.williams@bll.n-i.nhs.uk
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|