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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2003-12-30
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|
pubmed:abstractText |
Thiourea derivatives were identified as glyburide-reversible potassium channel openers through high-throughput screening. Based on these findings, a number of novel cyanoguanidines were designed and synthesized, which hyperpolarized human bladder K(ATP) channels. These agents are potent full agonists in relaxing electrically-stimulated pig bladder strips. The synthesis, SAR and biological properties of these agents are discussed.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0960-894X
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|
pubmed:author |
pubmed-author:BucknerSteven ASA,
pubmed-author:CarrollWilliam AWA,
pubmed-author:CoghlanMichael JMJ,
pubmed-author:GopalakrishnanMuraliM,
pubmed-author:GreggRobert JRJ,
pubmed-author:KortMichael EME,
pubmed-author:LynchJohn KJK,
pubmed-author:Perez-MedranoArturoA,
pubmed-author:ScottVictoria EVE,
pubmed-author:SullivanJames PJP,
pubmed-author:WhiteakerKristi LKL
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|
pubmed:issnType |
Print
|
|
pubmed:day |
19
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
397-400
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:14698167-Adenosine Triphosphate,
pubmed-meshheading:14698167-Animals,
pubmed-meshheading:14698167-Drug Design,
pubmed-meshheading:14698167-Guanidines,
pubmed-meshheading:14698167-Humans,
pubmed-meshheading:14698167-Muscle, Smooth,
pubmed-meshheading:14698167-Potassium Channels,
pubmed-meshheading:14698167-Swine,
pubmed-meshheading:14698167-Urinary Bladder,
pubmed-meshheading:14698167-Urinary Bladder Diseases
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|
pubmed:year |
2004
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|
pubmed:articleTitle |
Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.
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|
pubmed:affiliation |
Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com
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pubmed:publicationType |
Journal Article,
In Vitro
|
