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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-12-22
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pubmed:abstractText |
We describe 2 allogeneic stem cell transplantation patients who developed chronic graft-versus-host disease (GVHD) after dermatomal varicella-zoster virus (VZV) infection. Localized zoster did not respond to oral valaciclovir but did resolve with intravenous aciclovir. However, skin eruptions, eye/oral dryness, and liver dysfunction were observed at the healing stage of localized zoster, suggesting development of GVHD. Intensification of immunosuppressive therapy was required to control GVHD. Quantitative real-time PCR for VZV DNA was used to distinguish liver involvement by chronic GVHD from visceral dissemination of VZV in 1 patient. VZV infection may trigger chronic GVHD after allogeneic stem cell transplantation.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0925-5710
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pubmed:author |
pubmed-author:AokiKenichiK,
pubmed-author:GondoHisashiH,
pubmed-author:HaradaMineM,
pubmed-author:HayashiShinS,
pubmed-author:IinoTadafumiT,
pubmed-author:IshikawaFumihikoF,
pubmed-author:KamimuraTomohikoT,
pubmed-author:KawanoNoriakiN,
pubmed-author:KazuyamaYukumasaY,
pubmed-author:MiyamotoToshihiroT,
pubmed-author:NagafujiKojiK,
pubmed-author:OtsukaTeruhisaT,
pubmed-author:ShimodaKazuyaK
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pubmed:issnType |
Print
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|
pubmed:volume |
78
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
370-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14686497-Chickenpox,
pubmed-meshheading:14686497-Chronic Disease,
pubmed-meshheading:14686497-DNA, Viral,
pubmed-meshheading:14686497-Female,
pubmed-meshheading:14686497-Graft vs Host Disease,
pubmed-meshheading:14686497-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:14686497-Herpesvirus 3, Human,
pubmed-meshheading:14686497-Humans,
pubmed-meshheading:14686497-Immunosuppressive Agents,
pubmed-meshheading:14686497-Liver Diseases,
pubmed-meshheading:14686497-Male,
pubmed-meshheading:14686497-Middle Aged,
pubmed-meshheading:14686497-Transplantation, Homologous,
pubmed-meshheading:14686497-Treatment Outcome
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pubmed:year |
2003
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|
pubmed:articleTitle |
Chronic graft-versus-host disease following varicella-zoster virus infection in allogeneic stem cell transplant recipients.
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pubmed:affiliation |
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. kawano@1nai.med.kyushu-u.ac.jp
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|
