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rdf:type |
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lifeskim:mentions |
umls-concept:C0031727,
umls-concept:C0086418,
umls-concept:C0205314,
umls-concept:C0334227,
umls-concept:C0376358,
umls-concept:C0379310,
umls-concept:C0679622,
umls-concept:C0752313,
umls-concept:C0812215,
umls-concept:C1413259,
umls-concept:C1419281,
umls-concept:C1704259,
umls-concept:C1705121,
umls-concept:C1705987,
umls-concept:C1706586,
umls-concept:C1879547,
umls-concept:C1999216,
umls-concept:C2746015
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pubmed:issue |
1
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pubmed:dateCreated |
2003-12-15
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pubmed:abstractText |
The serine/threonine kinase Raf-1 is a major regulator of the mitogen activated protein kinase (MAPK) pathway, which has been associated with the progression of prostate cancer to the more advanced and androgen-independent disease. Cdc25A phosphatase has been implicated in the regulation of Raf-1 and the MAPK pathway.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,3-bis(2-hydroxyethylsulfanyl)-(1,4...,
http://linkedlifedata.com/resource/pubmed/chemical/Butadienes,
http://linkedlifedata.com/resource/pubmed/chemical/CDC25A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Leupeptins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-raf,
http://linkedlifedata.com/resource/pubmed/chemical/U 0126,
http://linkedlifedata.com/resource/pubmed/chemical/benzyloxycarbonylleucyl-leucyl-leuci...,
http://linkedlifedata.com/resource/pubmed/chemical/cdc25 Phosphatases
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-102
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14673957-Blotting, Western,
pubmed-meshheading:14673957-Butadienes,
pubmed-meshheading:14673957-Cell Line, Tumor,
pubmed-meshheading:14673957-Enzyme Inhibitors,
pubmed-meshheading:14673957-Humans,
pubmed-meshheading:14673957-Leupeptins,
pubmed-meshheading:14673957-MAP Kinase Signaling System,
pubmed-meshheading:14673957-Male,
pubmed-meshheading:14673957-Mitogen-Activated Protein Kinases,
pubmed-meshheading:14673957-Naphthoquinones,
pubmed-meshheading:14673957-Nitriles,
pubmed-meshheading:14673957-Phosphorylation,
pubmed-meshheading:14673957-Prostatic Neoplasms,
pubmed-meshheading:14673957-Proto-Oncogene Proteins c-raf,
pubmed-meshheading:14673957-cdc25 Phosphatases
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pubmed:year |
2004
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pubmed:articleTitle |
Activation of the Raf-1/MEK/Erk kinase pathway by a novel Cdc25 inhibitor in human prostate cancer cells.
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pubmed:affiliation |
Department of Urology, Nippon Medical School, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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