| pubmed-article:14671313 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14671313 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:14671313 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14671313 | lifeskim:mentions | umls-concept:C1655731 | lld:lifeskim |
| pubmed-article:14671313 | lifeskim:mentions | umls-concept:C0043297 | lld:lifeskim |
| pubmed-article:14671313 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:14671313 | lifeskim:mentions | umls-concept:C1699173 | lld:lifeskim |
| pubmed-article:14671313 | pubmed:issue | 5658 | lld:pubmed |
| pubmed-article:14671313 | pubmed:dateCreated | 2004-1-30 | lld:pubmed |
| pubmed-article:14671313 | pubmed:abstractText | The initiation of X-chromosome inactivation is thought to be tightly correlated with early differentiation events during mouse development. Here, we show that although initially active, the paternal X chromosome undergoes imprinted inactivation from the cleavage stages, well before cellular differentiation. A reversal of the inactive state, with a loss of epigenetic marks such as histone modifications and polycomb proteins, subsequently occurs in cells of the inner cell mass (ICM), which give rise to the embryo-proper in which random X inactivation is known to occur. This reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo. | lld:pubmed |
| pubmed-article:14671313 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14671313 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14671313 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14671313 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14671313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14671313 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14671313 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14671313 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:14671313 | pubmed:author | pubmed-author:HeardEdithE | lld:pubmed |
| pubmed-article:14671313 | pubmed:author | pubmed-author:AllisC... | lld:pubmed |
| pubmed-article:14671313 | pubmed:author | pubmed-author:OtteArie PAP | lld:pubmed |
| pubmed-article:14671313 | pubmed:author | pubmed-author:ReinbergDanny... | lld:pubmed |
| pubmed-article:14671313 | pubmed:author | pubmed-author:OkamotoIkuhir... | lld:pubmed |
| pubmed-article:14671313 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:14671313 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:14671313 | pubmed:volume | 303 | lld:pubmed |
| pubmed-article:14671313 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14671313 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14671313 | pubmed:pagination | 644-9 | lld:pubmed |
| pubmed-article:14671313 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:14671313 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14671313 | pubmed:articleTitle | Epigenetic dynamics of imprinted X inactivation during early mouse development. | lld:pubmed |
| pubmed-article:14671313 | pubmed:affiliation | CNRS UMR218, Curie Institute, 26 rue d'Ulm, Paris 75005, France. | lld:pubmed |
| pubmed-article:14671313 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14671313 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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