Solute(s) retained during uraemia cause increased exposure of aminophospholipid phosphatidylserine (PS) on the outer surface of erythrocyte membranes, and this phenomenon may be involved in the pathophysiology of uraemia by promoting abnormal erythrocyte interactions.
Institute of Nephrology and Biostatistical Laboratory, Department of Medicine, G. d'Annunzio University, SS Annunziata University Hospital, Via dei Vestini, 66013 Chieti, Italy. m.bonomini@nephro.unich.it