Source:http://linkedlifedata.com/resource/pubmed/id/14668389
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2003-12-11
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| pubmed:abstractText |
Population subdivision complicates analysis of molecular variation. Even if neutrality is assumed, three evolutionary forces need to be considered: migration, mutation, and drift. Simplification can be achieved by assuming that the process of migration among and drift within subpopulations is occurring fast compared to mutation and drift in the entire population. This allows a two-step approach in the analysis: (i) analysis of population subdivision and (ii) analysis of molecular variation in the migrant pool. We model population subdivision using an infinite island model, where we allow the migration/drift parameter Theta to vary among populations. Thus, central and peripheral populations can be differentiated. For inference of Theta, we use a coalescence approach, implemented via a Markov chain Monte Carlo (MCMC) integration method that allows estimation of allele frequencies in the migrant pool. The second step of this approach (analysis of molecular variation in the migrant pool) uses the estimated allele frequencies in the migrant pool for the study of molecular variation. We apply this method to a Drosophila ananassae sequence data set. We find little indication of isolation by distance, but large differences in the migration parameter among populations. The population as a whole seems to be expanding. A population from Bogor (Java, Indonesia) shows the highest variation and seems closest to the species center.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-10353916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-10581291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-10880480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-11172082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-11287657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-11302758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-1145509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-12493913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-1360932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-16588627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-17246615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-2513255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-2563714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-2577362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-3149056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-7607457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-9203353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-9576938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14668389-9615475
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0016-6731
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
165
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1385-95
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| pubmed:dateRevised |
2009-11-18
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| pubmed:meshHeading | |
| pubmed:year |
2003
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| pubmed:articleTitle |
Population subdivision and molecular sequence variation: theory and analysis of Drosophila ananassae data.
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| pubmed:affiliation |
Department Biologie II, Ludwig-Maximilians Universität, D-80333 München, Germany. vogl@i122server.vu-wien.ac.at
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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