Linked Life Data

14665417

Source:http://linkedlifedata.com/resource/pubmed/id/14665417

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-12-10
pubmed:abstractText
Using the cardiac dialysis technique in the anesthetized cat, we examined the effects of NG-nitro-L-arginine methyl ester (L-NAME, a nitric oxide (NO) synthase inhibitor, 100 mM) on sympathetic modulation. Local administration of L-NAME induced increases in dialysate norepinephrine (NE) levels, which were not affected by the addition of omega-conotoxinGVIA. High-potassium (high K+)-evoked increases in dialysate NE levels were suppressed by addition of L-NAME. To confirm the involvement of NO in the NE releasing action, we compared dialysate NE levels during the administration of L-NAME or D-NAME and no significant differences between them. L-NAME induces spontaneous non-exocytotic NE release but suppresses exocytotic NE release by high K+. L-NAME may interact with both NE transport and NE release mechanisms. However, NO may contribute little to the amounts of NE released by L-NAME.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
353
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
NG-nitro-L-arginine methyl ester-induced norepinephrine release from cardiac sympathetic nerve endings in anesthetized cats.
pubmed:affiliation
Department of Anesthesiology and Surgical Intensive Care Unit, National Cardiovascular Center, Suita, Osaka 565-8565, Japan.
pubmed:publicationType
Journal Article, Comparative Study