| pubmed-article:14663204 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14663204 | lifeskim:mentions | umls-concept:C0011065 | lld:lifeskim |
| pubmed-article:14663204 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:14663204 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:14663204 | lifeskim:mentions | umls-concept:C0035871 | lld:lifeskim |
| pubmed-article:14663204 | lifeskim:mentions | umls-concept:C0282151 | lld:lifeskim |
| pubmed-article:14663204 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:14663204 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:14663204 | pubmed:dateCreated | 2003-12-9 | lld:pubmed |
| pubmed-article:14663204 | pubmed:abstractText | Mitochondrial complex I activity is partially suppressed in patients with Parkinson's disease, which is characterized by dopaminergic neuronal death. However, the precise relationship between neuronal death and mitochondrial complex I suppression has been unresolved. We investigated the involvement of superoxide and endogenous dopamine in neurotoxicity by rotenone, a complex I inhibitor. A short exposure to rotenone at high concentrations reduced the viability of both dopaminergic and non-dopaminergic neurons. The toxicity was significantly prevented by a membrane-permeable superoxide dismutase mimetic and alpha-methyl-p-tyrosine (alpha-MT), a tyrosine hydroxylase inhibitor. Chronic treatment with low-concentration rotenone caused selective toxicity to dopaminergic neurons, and this toxicity was attenuated by alpha-MT. These data suggest that superoxide and endogenous dopamine play an important role in dopaminergic neuronal loss. | lld:pubmed |
| pubmed-article:14663204 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14663204 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14663204 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14663204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14663204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14663204 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14663204 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14663204 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:14663204 | pubmed:author | pubmed-author:ShimohamaShun... | lld:pubmed |
| pubmed-article:14663204 | pubmed:author | pubmed-author:KanekoShujiS | lld:pubmed |
| pubmed-article:14663204 | pubmed:author | pubmed-author:AkaikeAkinori... | lld:pubmed |
| pubmed-article:14663204 | pubmed:author | pubmed-author:KatsukiHirosh... | lld:pubmed |
| pubmed-article:14663204 | pubmed:author | pubmed-author:KumeToshiakiT | lld:pubmed |
| pubmed-article:14663204 | pubmed:author | pubmed-author:SawadaHideyuk... | lld:pubmed |
| pubmed-article:14663204 | pubmed:author | pubmed-author:SakkaNorikoN | lld:pubmed |
| pubmed-article:14663204 | pubmed:author | pubmed-author:IzumiYasuhiko... | lld:pubmed |
| pubmed-article:14663204 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14663204 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:14663204 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:14663204 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14663204 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14663204 | pubmed:pagination | 2425-8 | lld:pubmed |
| pubmed-article:14663204 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:meshHeading | pubmed-meshheading:14663204... | lld:pubmed |
| pubmed-article:14663204 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14663204 | pubmed:articleTitle | Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone. | lld:pubmed |
| pubmed-article:14663204 | pubmed:affiliation | Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan. | lld:pubmed |
| pubmed-article:14663204 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14663204 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14663204 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14663204 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14663204 | lld:pubmed |
