Linked Life Data

14663204

Source:http://linkedlifedata.com/resource/pubmed/id/14663204

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2003-12-9
pubmed:abstractText
Mitochondrial complex I activity is partially suppressed in patients with Parkinson's disease, which is characterized by dopaminergic neuronal death. However, the precise relationship between neuronal death and mitochondrial complex I suppression has been unresolved. We investigated the involvement of superoxide and endogenous dopamine in neurotoxicity by rotenone, a complex I inhibitor. A short exposure to rotenone at high concentrations reduced the viability of both dopaminergic and non-dopaminergic neurons. The toxicity was significantly prevented by a membrane-permeable superoxide dismutase mimetic and alpha-methyl-p-tyrosine (alpha-MT), a tyrosine hydroxylase inhibitor. Chronic treatment with low-concentration rotenone caused selective toxicity to dopaminergic neurons, and this toxicity was attenuated by alpha-MT. These data suggest that superoxide and endogenous dopamine play an important role in dopaminergic neuronal loss.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2425-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone.
pubmed:affiliation
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't