| pubmed-article:1464496 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1464496 | lifeskim:mentions | umls-concept:C0005855 | lld:lifeskim |
| pubmed-article:1464496 | lifeskim:mentions | umls-concept:C0060933 | lld:lifeskim |
| pubmed-article:1464496 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:1464496 | lifeskim:mentions | umls-concept:C0060934 | lld:lifeskim |
| pubmed-article:1464496 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:1464496 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:1464496 | lifeskim:mentions | umls-concept:C0443131 | lld:lifeskim |
| pubmed-article:1464496 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:1464496 | pubmed:dateCreated | 1993-1-15 | lld:pubmed |
| pubmed-article:1464496 | pubmed:abstractText | Dynamic T1-weighted magnetic resonance imaging (MRI) after the injection of Gd-DTPA is a promising method for investigating breakdown of the blood-retinal barrier (BRB). Previously, the authors demonstrated that in a T1-weighted image, the initial rate of change in the vitreous water MRI signal as gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) enters the vitreous space strongly correlated with the extent of BRB breakdown. Here, a practical approach to measuring a more relevant physiologic parameter is presented: the permeability surface area product (PS). The theory is a development of earlier work used in investigating the breakdown of the blood-brain barrier. The accuracy and precision of this approach was investigated in rabbits pretreated with sodium iodate (30 mg/kg intravenously). The MRI-derived PS normalized to the area of leaky retina (5.65 +/- 0.25 x 10(-4) cm/min, mean +/- standard error of the mean; n = 6) was compared to a similarly normalized PS calculated using a classical physiologic method (4.12 +/- 0.73 x 10(-4) cm/min; n = 6). Good agreement between the two methods was found (P = 0.09). This result demonstrates that the MRI-derived PS is an accurate and precise measure of BRB breakdown under these conditions. The mathematical model of Gd-DTPA distribution in vivo also is validated. Based on these results, several potential sources of error are discussed, including the effect of back-flow of Gd-DTPA from the vitreous space to the plasma, the underlying vascular patency, and MRI slice selection. | lld:pubmed |
| pubmed-article:1464496 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1464496 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1464496 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1464496 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1464496 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1464496 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1464496 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1464496 | pubmed:issn | 0146-0404 | lld:pubmed |
| pubmed-article:1464496 | pubmed:author | pubmed-author:BerkowitzB... | lld:pubmed |
| pubmed-article:1464496 | pubmed:author | pubmed-author:AndoNN | lld:pubmed |
| pubmed-article:1464496 | pubmed:author | pubmed-author:ToftsP SPS | lld:pubmed |
| pubmed-article:1464496 | pubmed:author | pubmed-author:de JuanEEJr | lld:pubmed |
| pubmed-article:1464496 | pubmed:author | pubmed-author:SenH AHA | lld:pubmed |
| pubmed-article:1464496 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1464496 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:1464496 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1464496 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1464496 | pubmed:pagination | 3500-6 | lld:pubmed |
| pubmed-article:1464496 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1464496 | pubmed:meshHeading | pubmed-meshheading:1464496-... | lld:pubmed |
| pubmed-article:1464496 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1464496 | pubmed:articleTitle | Accurate and precise measurement of blood-retinal barrier breakdown using dynamic Gd-DTPA MRI. | lld:pubmed |
| pubmed-article:1464496 | pubmed:affiliation | National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. | lld:pubmed |
| pubmed-article:1464496 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1464496 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1464496 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1464496 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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