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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
13
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pubmed:dateCreated |
1993-1-15
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pubmed:abstractText |
Dynamic T1-weighted magnetic resonance imaging (MRI) after the injection of Gd-DTPA is a promising method for investigating breakdown of the blood-retinal barrier (BRB). Previously, the authors demonstrated that in a T1-weighted image, the initial rate of change in the vitreous water MRI signal as gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) enters the vitreous space strongly correlated with the extent of BRB breakdown. Here, a practical approach to measuring a more relevant physiologic parameter is presented: the permeability surface area product (PS). The theory is a development of earlier work used in investigating the breakdown of the blood-brain barrier. The accuracy and precision of this approach was investigated in rabbits pretreated with sodium iodate (30 mg/kg intravenously). The MRI-derived PS normalized to the area of leaky retina (5.65 +/- 0.25 x 10(-4) cm/min, mean +/- standard error of the mean; n = 6) was compared to a similarly normalized PS calculated using a classical physiologic method (4.12 +/- 0.73 x 10(-4) cm/min; n = 6). Good agreement between the two methods was found (P = 0.09). This result demonstrates that the MRI-derived PS is an accurate and precise measure of BRB breakdown under these conditions. The mathematical model of Gd-DTPA distribution in vivo also is validated. Based on these results, several potential sources of error are discussed, including the effect of back-flow of Gd-DTPA from the vitreous space to the plasma, the underlying vascular patency, and MRI slice selection.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Contrast Media,
http://linkedlifedata.com/resource/pubmed/chemical/Gadolinium,
http://linkedlifedata.com/resource/pubmed/chemical/Gadolinium DTPA,
http://linkedlifedata.com/resource/pubmed/chemical/Iodates,
http://linkedlifedata.com/resource/pubmed/chemical/Organometallic Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Pentetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/sodium iodate
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0146-0404
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3500-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1464496-Animals,
pubmed-meshheading:1464496-Blood-Retinal Barrier,
pubmed-meshheading:1464496-Cell Membrane Permeability,
pubmed-meshheading:1464496-Contrast Media,
pubmed-meshheading:1464496-Female,
pubmed-meshheading:1464496-Gadolinium,
pubmed-meshheading:1464496-Gadolinium DTPA,
pubmed-meshheading:1464496-Iodates,
pubmed-meshheading:1464496-Magnetic Resonance Imaging,
pubmed-meshheading:1464496-Male,
pubmed-meshheading:1464496-Mathematics,
pubmed-meshheading:1464496-Organometallic Compounds,
pubmed-meshheading:1464496-Pentetic Acid,
pubmed-meshheading:1464496-Rabbits,
pubmed-meshheading:1464496-Reproducibility of Results,
pubmed-meshheading:1464496-Retinal Diseases,
pubmed-meshheading:1464496-Vitreous Body
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pubmed:year |
1992
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pubmed:articleTitle |
Accurate and precise measurement of blood-retinal barrier breakdown using dynamic Gd-DTPA MRI.
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pubmed:affiliation |
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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