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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
24
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|
pubmed:dateCreated |
2003-12-3
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|
pubmed:abstractText |
Phosphonoacetamido(oxy) groups have proven to be good mimics of the diphosphate portion in geranylgeranyl protein transferase I (GGTase I) inhibitors. The introduction of small alkyl groups (Me, Et) into the diphosphate mimic moiety caused a further decrease in collateral farnesyl protein transferase (FTase) inhibitory activity, thereby improving GGTase I over FTase selectivity.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Dec
|
|
pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BarontiniSilviaS,
pubmed-author:BertiniSimoneS,
pubmed-author:BettiLauraL,
pubmed-author:DanesiRomanoR,
pubmed-author:GervasiGianbattistaG,
pubmed-author:GiannacciniGinoG,
pubmed-author:MacchiaMarcoM,
pubmed-author:MinutoloFilippoF,
pubmed-author:PapiChiaraC,
pubmed-author:PlacanicaGiorgioG,
pubmed-author:RapposelliSimonaS
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|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4405-8
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|
pubmed:dateRevised |
2008-9-20
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pubmed:meshHeading |
|
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pubmed:year |
2003
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|
pubmed:articleTitle |
Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.
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|
pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.
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|
pubmed:publicationType |
Journal Article,
Comparative Study
|
