Linked Life Data

14643026

Source:http://linkedlifedata.com/resource/pubmed/id/14643026

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-12-3
pubmed:abstractText
Recent studies have indicated that the prostate-specific antigen (PSA) gene polymorphisms may be associated with the risk of prostate cancer in Caucasian populations. To verify the association, we examined the PSA polymorphisms at positions -158 and -252 in 300 prostate cancer cases, 216 benign prostatic hyperplasia (BPH) cases, and 266 controls by the PCR-restriction fragment length polymorphism analysis. Regarding the PSA polymorphism at position -158, the A allele was less common in the Japanese population (A 0.22, G 0.78) than that in other ethnic populations (A 0.37-0.52, G 0.48-0.63). No significant associations were found between the polymorphism and the risks of prostate cancer (P=0.530) and BPH (P=0.740) and between the polymorphism and the serum PSA level (P=0.626). As for the polymorphism at position -252, no significant results were also found. In conclusion, the PSA polymorphisms may not be associated with the risk of prostate cancer development and its disease progression and the risk of BPH in Japanese men, and may also be not related to the serum PSA level in Japanese men with prostate cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
202
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:14643026-Aged, pubmed-meshheading:14643026-Case-Control Studies, pubmed-meshheading:14643026-DNA, pubmed-meshheading:14643026-Deoxyribonucleases, Type II Site-Specific, pubmed-meshheading:14643026-Genotype, pubmed-meshheading:14643026-Humans, pubmed-meshheading:14643026-Japan, pubmed-meshheading:14643026-Male, pubmed-meshheading:14643026-Polymorphism, Genetic, pubmed-meshheading:14643026-Polymorphism, Restriction Fragment Length, pubmed-meshheading:14643026-Promoter Regions, Genetic, pubmed-meshheading:14643026-Prostate, pubmed-meshheading:14643026-Prostate-Specific Antigen, pubmed-meshheading:14643026-Prostatic Hyperplasia, pubmed-meshheading:14643026-Prostatic Neoplasms, pubmed-meshheading:14643026-Risk Factors, pubmed-meshheading:14643026-Transurethral Resection of Prostate
pubmed:year
2003
pubmed:articleTitle
Polymorphisms in prostate-specific antigen (PSA) gene, risk of prostate cancer, and serum PSA levels in Japanese population.
pubmed:affiliation
Department of Urology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Multicenter Study