|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
25
|
|
pubmed:dateCreated |
2003-12-3
|
|
pubmed:abstractText |
A series of A-ring polymethoxylated neoflavonoids was prepared by ligand coupling reactions involving either Suzuki or Stille reactions. Cytotoxicity studies indicated a potent activity against a CEM leukemia cell line for the compounds presenting a substitution pattern related to that of combretastatin A-4. The two compounds having a 3'-OH and a 4'-OCH(3) substituents on the 4-phenyl B-ring have no effect on human topoisomerases I and II but potently inhibit, in vitro, microtubule assembly. At the cell level, the active compounds were characterized as proapoptotic agents, but they can also trigger cell death via a nonapoptotic pathway.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Biopolymers,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Topoisomerases, Type I,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Topoisomerases, Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Stilbenes,
http://linkedlifedata.com/resource/pubmed/chemical/Topoisomerase I Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Topoisomerase II Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Tubulin,
http://linkedlifedata.com/resource/pubmed/chemical/combretastatin A-4
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
4
|
|
pubmed:volume |
46
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5437-44
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:14640552-Antineoplastic Agents,
pubmed-meshheading:14640552-Apoptosis,
pubmed-meshheading:14640552-Biopolymers,
pubmed-meshheading:14640552-Caspases,
pubmed-meshheading:14640552-Cell Cycle,
pubmed-meshheading:14640552-Cell Line, Tumor,
pubmed-meshheading:14640552-DNA Topoisomerases, Type I,
pubmed-meshheading:14640552-DNA Topoisomerases, Type II,
pubmed-meshheading:14640552-Drug Screening Assays, Antitumor,
pubmed-meshheading:14640552-Enzyme Activation,
pubmed-meshheading:14640552-Flow Cytometry,
pubmed-meshheading:14640552-Humans,
pubmed-meshheading:14640552-Membrane Potentials,
pubmed-meshheading:14640552-Mitochondria,
pubmed-meshheading:14640552-Stilbenes,
pubmed-meshheading:14640552-Structure-Activity Relationship,
pubmed-meshheading:14640552-Topoisomerase I Inhibitors,
pubmed-meshheading:14640552-Topoisomerase II Inhibitors,
pubmed-meshheading:14640552-Tubulin
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins.
|
|
pubmed:affiliation |
INSERM U-524 et Laboratoire de Pharmacologie antitumorale du Centre Oscar Lambret, Institut de Recherches sur le Cancer, Place de Verdun, 59045 Lille, France. bailly@lille.inserm.fr
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
