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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2003-11-19
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pubmed:abstractText |
Lack of a vaccine for infants and immunosuppression after infection are problems associated with measles virus (MV). Because interleukin (IL)-12 has been used successfully as a vaccine adjuvant and because inhibition of IL-12 expression has been associated with immunosuppression during measles, the addition of IL-12 may enhance the immune response to MV. To determine the effect of IL-12 supplementation, rhesus macaques were vaccinated with a recombinant MV expressing IL-12; these macaques had increased interferon-gamma production by CD4(+) T cells, decreased production of IL-4, and lower levels of MV-specific immunoglobulin G4 and neutralizing antibody. Lymphoproliferative responses to mitogen were not improved. IL-12 supplementation altered the T helper type 2 bias of the immune response after MV vaccination, had a detrimental effect on the protective neutralizing antibody response, and did not improve other manifestations of immunosuppression. Reduced IL-12 levels are not the sole factor in MV-induced immunosuppression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Granzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Synthetic,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Vaccines
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
188
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1553-61
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14624382-Adjuvants, Immunologic,
pubmed-meshheading:14624382-Animals,
pubmed-meshheading:14624382-Antibodies, Viral,
pubmed-meshheading:14624382-Cytokines,
pubmed-meshheading:14624382-Flow Cytometry,
pubmed-meshheading:14624382-Granzymes,
pubmed-meshheading:14624382-Immunoenzyme Techniques,
pubmed-meshheading:14624382-Interleukin-12,
pubmed-meshheading:14624382-Leukocytes, Mononuclear,
pubmed-meshheading:14624382-Macaca mulatta,
pubmed-meshheading:14624382-Measles,
pubmed-meshheading:14624382-Measles virus,
pubmed-meshheading:14624382-RNA, Viral,
pubmed-meshheading:14624382-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:14624382-Serine Endopeptidases,
pubmed-meshheading:14624382-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:14624382-Vaccination,
pubmed-meshheading:14624382-Vaccines, Synthetic,
pubmed-meshheading:14624382-Viral Vaccines
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pubmed:year |
2003
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pubmed:articleTitle |
Vaccination of rhesus macaques with a recombinant measles virus expressing interleukin-12 alters humoral and cellular immune responses.
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pubmed:affiliation |
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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