Linked Life Data

14623880

Source:http://linkedlifedata.com/resource/pubmed/id/14623880

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2004-2-9
pubmed:abstractText
Mammalian voltage-gated K+ channels are assemblies of pore-forming alpha-subunits and modulating beta-subunits. To operate correctly, Kv4 alpha-subunits in the heart and central nervous system require recently identified beta-subunits of the neuronal calcium sensing protein family called K+ channel-interacting proteins (KChIPs). Here, Kv4.2.KChIP2 channels are purified, integrity of isolated complexes confirmed, molar ratio of the subunits determined, and subunit valence established. A complex has 4 subunits of each type, a stoichiometry expected for other channels employing neuronal calcium sensing beta-subunits.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
279
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5549-54
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:14623880-Animals, pubmed-meshheading:14623880-COS Cells, pubmed-meshheading:14623880-Calcium-Binding Proteins, pubmed-meshheading:14623880-Centrifugation, Density Gradient, pubmed-meshheading:14623880-Charybdotoxin, pubmed-meshheading:14623880-Dose-Response Relationship, Drug, pubmed-meshheading:14623880-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:14623880-Electrophysiology, pubmed-meshheading:14623880-Glycerol, pubmed-meshheading:14623880-Humans, pubmed-meshheading:14623880-Ions, pubmed-meshheading:14623880-Kv Channel-Interacting Proteins, pubmed-meshheading:14623880-Potassium Channels, pubmed-meshheading:14623880-Potassium Channels, Voltage-Gated, pubmed-meshheading:14623880-Protein Binding, pubmed-meshheading:14623880-Shal Potassium Channels, pubmed-meshheading:14623880-Time Factors, pubmed-meshheading:14623880-Xenopus laevis
pubmed:year
2004
pubmed:articleTitle
Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2.
pubmed:affiliation
Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't