Linked Life Data

14622433

Source:http://linkedlifedata.com/resource/pubmed/id/14622433

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2003-11-19
pubmed:abstractText
Food restriction prolongs lactational infertility in rats. Here, we investigated whether an attenuated response to the positive-feedback effects of oestrogen on luteinizing hormone release contributed to this effect. The ability of oestrogen to induce surges in luteinizing hormone in ad libitum fed and food-restricted dams at different times of lactation was compared. The results showed that, on day 20 postpartum, ad libitum fed dams showed luteinizing hormone surges after oestrogen treatment, but food-restricted dams did not. Ovariectomy or RU486 treatment restored the ability of oestrogen to induce luteinizing hormone surges in food-restricted dams, and chronic progesterone exposure reduced oestrogen-induced surges of luteinizing hormone in ad libitum fed ovariectomized dams. Food restriction also resulted in a reduced ability of oestrogen to induce progesterone receptor immunoreactivity, but did not reduce the number of oestrogen receptors (ERalpha) in the anteroventralperiventricular area. As with the surge in luteinizing hormone, the effects of food restriction on oestrogen induction of progesterone receptors were mediated by progesterone. Together, these results suggest that the ability of food restriction to extend the length of lactational diestrus is mediated, in part, by a decrease in sensitivity to the positive-feedback effects of oestrogen. This results from high circulating concentrations of progesterone which apparently reduce the ability of oestrogen to induce progesterone receptor expression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0953-8194
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1037-45
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:14622433-Animals, pubmed-meshheading:14622433-Estradiol, pubmed-meshheading:14622433-Estrogen Receptor alpha, pubmed-meshheading:14622433-Estrous Cycle, pubmed-meshheading:14622433-Feedback, Physiological, pubmed-meshheading:14622433-Female, pubmed-meshheading:14622433-Food Deprivation, pubmed-meshheading:14622433-Hormone Antagonists, pubmed-meshheading:14622433-Immunohistochemistry, pubmed-meshheading:14622433-Lactation, pubmed-meshheading:14622433-Luteinizing Hormone, pubmed-meshheading:14622433-Midline Thalamic Nuclei, pubmed-meshheading:14622433-Mifepristone, pubmed-meshheading:14622433-Ovariectomy, pubmed-meshheading:14622433-Progesterone, pubmed-meshheading:14622433-Rats, pubmed-meshheading:14622433-Rats, Wistar, pubmed-meshheading:14622433-Receptors, Estrogen, pubmed-meshheading:14622433-Receptors, Progesterone
pubmed:year
2003
pubmed:articleTitle
Food restriction during lactation results in prolonged hyposensitivity to the positive-feedback effects of oestradiol.
pubmed:affiliation
Center for Studies in Behavioral Neurobiology, Concordia University, Montréal, Quebec, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't