Linked Life Data

14615400

Source:http://linkedlifedata.com/resource/pubmed/id/14615400

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-11-17
pubmed:abstractText
Voltage-dependent potassium channels (Kv channels) are important determinants of brain electrical activity. Hypoxia may be an important modifier, because several voltage-gated K+ channels are reversibly blocked by acute hypoxia and are thought to act as oxygen sensors. Here we show, using the anoxia-tolerant turtle brain (Trachemys scripta) as a model, that brain Kv1 channel transcription is reversibly regulated by oxygen supply. We found that in turtle brains exposed to 4-h anoxia Kv1 transcripts were reduced to 18.5% of normoxic levels. Kv1 channel mRNA levels were restored to normal within 4 h of subsequent reoxygenation. Our results provide clear evidence that brain Kv channel expression is sensitive to oxygen supply and indicate an important mechanism that matches brain activity to oxygen supply.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0363-6119
pubmed:author
pubmed:issnType
Print
pubmed:volume
285
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1317-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Gene transcription of brain voltage-gated potassium channels is reversibly regulated by oxygen supply.
pubmed:affiliation
Department of Biomedical Sciences, Florida Atlantic University, Boca Raton 33431, USA. hprentic@fau.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't