Source:http://linkedlifedata.com/resource/pubmed/id/14614853
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2003-11-17
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pubmed:abstractText |
WSX-1 is a class I cytokine receptor with homology to the IL-12 receptors and is essential for resistance to Leishmania major infection. In the present study, we demonstrated that WSX-1 was also required for resistance to Trypanosoma cruzi. WSX-1-/- mice exhibited prolonged parasitemia, severe liver injury, and increased mortality over wild-type mice. WSX-1-/- splenocytes produced enhanced levels of Th2 cytokines, which were responsible for the prolonged parasitemia. Massive necroinflammatory lesions were observed in the liver of infected WSX-1-/- mice, and IFN-gamma that was overproduced in WSX-1-/- mice compared with wild-type mice was responsible for the lesions. In addition, vast amounts of various proinflammatory cytokines, including IL-6 and TNF-alpha, were produced by liver mononuclear cells in WSX-1-/- mice. Thus, during T. cruzi infection, WSX-1 suppresses liver injury by regulating production of proinflammatory cytokines, while controlling parasitemia by suppression of Th2 responses, demonstrating its novel role as an inhibitory regulator of cytokine production.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1074-7613
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pubmed:author |
pubmed-author:HamanoShinjiroS,
pubmed-author:HimenoKunisukeK,
pubmed-author:HisaedaHajimeH,
pubmed-author:IshiiKazunariK,
pubmed-author:MakTak WTW,
pubmed-author:MiyazakiYoshiyukiY,
pubmed-author:TakedaAtsunobuA,
pubmed-author:YamanakaAtsushiA,
pubmed-author:YoshidaHirokiH,
pubmed-author:YoshimuraAkihikoA,
pubmed-author:ZhangManxinM
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
657-67
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14614853-Animals,
pubmed-meshheading:14614853-Blood,
pubmed-meshheading:14614853-Chagas Disease,
pubmed-meshheading:14614853-Cytokines,
pubmed-meshheading:14614853-Liver,
pubmed-meshheading:14614853-Mice,
pubmed-meshheading:14614853-Mice, Knockout,
pubmed-meshheading:14614853-Receptors, Cytokine,
pubmed-meshheading:14614853-Spleen,
pubmed-meshheading:14614853-Th2 Cells,
pubmed-meshheading:14614853-Trypanosoma cruzi
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pubmed:year |
2003
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pubmed:articleTitle |
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production.
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pubmed:affiliation |
The Department of Parasitology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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